Search

Kissoon, Niranjan; Fung, Jollee; Hwang, Bella; Trawin, Jessica; Symonds, Nicola; Knappett, Martina; Krepiakevich, Alexia; Liu, Christine; Businge, Stephen; Jabornisky, Roberto; Suiyven, Dzelamunyuy; Talla, Emmanuela; Nwankwor, Odiraa; Tagoola, Abner; Oguonu, Tagbo; Karlovich, Gabrielle; Kenechi, Onah Stanley; Dunsmuir, Dustin; Wiens, Matthew; Ansermino, J Mark — 2020-04-17 The purpose of this environmental scan is to support health facilities in identifying and assessing quality improvement (QI) priorities and initiatives to treat children with sepsis. <br /> <br /><strong><u>Tools Description:</strong></u> <br /><strong>Step 1 Environmental Scan</strong> - A health facility survey that gathers information regarding (1) the availability of resources and services in the health facility and (2) the readiness of the health facility to provide specific services to a defined minimum standard. <br /><strong>Step 2 Technology Readiness Scan</strong> - A short survey that aims to assess a facility’s level of technological preparedness for facilitating standard triage and discharge processes. Ultimately, it determines what technology is needed in order to effectively implement quality improvement intervention. <br /><strong>Step 3a-f Observational Scan</strong> - Assesses the quality and safety of care through observation of a health worker in suspected cases of pneumonia, diarrhea, and malaria, in order to assess adherence to standards in the patient care process. <br /><strong>Step 4 Caretaker Satisfaction Questionnaire</strong> - Assesses the patient-caretakers’ perspective of the quality of care they/their child received while at the facility. <br /><strong>Step 5 Health Worker Satisfaction Questionnaire</strong> - Assesses health workers’ perspectives of the quality of care provided at the facility. <br /><strong>Environmental Scan Feedback Survey</strong> - To be completed by data collector(s) and asks questions pertaining to the Scan’s relevancy and usability. The intention of this form is to collect suggestions on what elements of the Scan to add, eliminate, or modify to inform future module updates. <br /><strong>Written Report Of Results Feedback Survey</strong> - This survey asks questions pertaining to the presentation and value of the results report. <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Wiens, Matthew O; Bone, Jeffrey N; Kumbakumba, Elias; Businge, Stephen; Tagoola, Abner; Sherine, Sheila Oyella; Byaruhanga, Emmanuel; Ssemwanga, Edward; Barigye, Celestine; Nsungwa, Jesca; Olaro, Charles; Ansermino, J Mark; Kissoon, Niranjan; Singer, Joel; Larson, Charles P; Lavoie, Pascal M; Dunsmuir, Dustin; Moschovis, Peter P; Novakowski, Stefanie; Komugisha, Clare; Tayebwa, Mellon; Mwesignwa, Douglas; Knappett, Martina; West, Nicholas; Nguyen, Vuong; Mugisha, Nathan-Kenya; Kabakyenga, Jerome — 2022-12-06 <br /><strong>Background:</strong> Substantial mortality occurs after hospital discharge in children younger than 5 years with suspected sepsis, especially in low-income countries. A better understanding of its epidemiology is needed for effective interventions to reduce child mortality in these countries. We evaluated risk factors for death after discharge in children admitted to hospital for suspected sepsis in Uganda, and assessed how these differed by age, time of death, and location of death. <br /> <br /><strong>Methods:</strong> In this prospective observational cohort study, we recruited 0-60-month-old children admitted with suspected sepsis from the community to the paediatric wards of six Ugandan hospitals. The primary outcome was six-month post-discharge mortality among those discharged alive. We evaluated the interactive impact of age, time of death, and location of death on risk factors for mortality.<br /> <br /><strong>Findings:</strong> 6,545 children were enrolled, with 6,191 discharged alive. The median (interquartile range) time from discharge to death was 28 (9-74) days, with a six-month post-discharge mortality rate of 5·5%, constituting 51% of total mortality. Deaths occurred at home (45%), in-transit to care (18%), or in hospital (37%) during a subsequent readmission. Post-discharge death was strongly associated with weight-for-age z-scores < -3 (adjusted risk ratio [aRR] 4·7, 95% CI 3·7–5·8 vs a Z score of >–2), referral for further care (7·3, 5·6–9·5), and unplanned discharge (3·2, 2·5–4·0). The hazard ratio of those with severe anaemia increased with time since discharge, while the hazard ratios of discharge vulnerabilities (unplanned, poor feeding) decreased with time. Age influenced the effect of several variables, including anthropometric indices (less impact with increasing age), anaemia (greater impact), and admission temperature (greater impact).<br /> <br /><strong>Data Collection Methods:</strong> All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.<br /> <br /><strong>Data Processing Methods:</strong> For this analysis, data from both cohorts (0-6 months and 6-60 months) were combined and analysed as a single dataset. We used periods of overlapping enrolment (72% of total enrolment months) between the two cohorts to determine site-specific proportions of children who were 0-6 and 6-60 months of age. These proportions were used to weight the cohorts for the calculation of overall mortality rate. Z-scores were calculated using height and weight. Hematocrit was converted to hemoglobin. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.<br /> <br /><strong>Abbreviations:</strong><br /> MUAC -mid upper arm circumference<br /> wfa – weight for age<br /> wfl – weight for length<br /> bmi – body mass index<br /> lfa – length for age<br /> abx - antibiotics<br /> hr – heart rate<br /> rr – respiratory rate<br /> antimal - antimalarial<br /> sysbp – systolic blood pressure<br /> diasbp – diastolic blood pressure<br /> resp – respiratory<br /> cap - capillary<br /> BCS - Blantyre Coma Scale<br /> dist- distance<br /> hos - hospital<br /> ed - education<br /> disch - discharge<br /> dis -discharge<br /> fu – follow-up<br /> pd – post-discharge<br /> loc - location<br /> materl - maternal<br /> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).<br /> <br /><strong>Study Protocol & Supplementary Materials:</strong> <br /> <a href = "https://borealisdata.ca/dataset.xhtml?persistentId=doi%3A10.5683%2FSP3%2FQRUMNQ&version=1.0">Smart Discharges to improve post-discharge health outcomes in children: A prospective before-after study with staggered implementation </a><br /> <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator at <a href = mailto:sepsiscolab@bccchr.ca>sepsiscolab@bcchr.ca</a> or visit our <a href = "https://wfpiccs.org/pediatric-sepsis-colab/">website</a>.

Kissoon, Niranjan; Fung, Jollee; Hwang, Bella; Trawin, Jessica; Krepiakevich, Alexia; Symonds, Nicola; Knappett, Martina; Liu, Christine; Businge, Stephen; Jabornisky, Roberto; Suiyven, Dzelamunyuy; Talla, Emmanuela; Nwankwor, Odiraa; Tagoola, Abner; Oguonu, Tagbo; Karlovich, Gabrielle; Kenechi, Onah Stanley; Dunsmuir, Dustin; Wiens, Matthew; Ansermino, J Mark — 2021-06-24 The purpose of this environmental scan is to support health facilities in identifying and assessing quality improvement (QI) priorities and initiatives to treat children with sepsis. This dataset contains training materials for project setup and data collection. <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Kissoon, Niranjan; Fung, Jollee; Hwang, Bella; Trawin, Jessica; Symonds, Nicola; Knappett, Martina; Krepiakevich, Alexia; Liu, Christine; Businge, Stephen; Jabornisky, Roberto; Suiyven, Dzelamunyuy; Talla, Emmanuela; Nwankwor, Odiraa; Tagoola, Abner; Oguonu, Tagbo; Karlovich, Gabrielle; Kenechi, Onah Stanley; Dunsmuir, Dustin; Wiens, Matthew; Ansermino, J Mark — 2021-08-03 The purpose of this environmental scan is to support health facilities in identifying and assessing quality improvement (QI) priorities and initiatives to treat children with sepsis. This dataset contains generic protocol and templates, written consent form templates, and verbal consent scripts to assist project teams in the ethics application process. <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Kumbakumba, Elias; Kabakyenga, Jerome; Wiens, Matthew; Lavoie, Pascal; Businge, Stephen; Tagoola, Abner; Kenya Mugisha, Nathan; Ansermino, J Mark; Kissoon, Niranjan (Tex) — 2021-03-30 Pulse oximetry dataset from Smart Discharges <6m observational study. May 2017 to March, 2020 (Thrasher - <6m - Phase 1) <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Kumbakumba, Elias; Kabakyenga, Jerome; Wiens, Matthew; Lavoie, Pascal; Businge, Stephen; Tagoola, Abner; Kenya Mugisha, Nathan; Ansermino, J Mark; Kissoon, Niranjan (Tex) — 2021-04-20 Clinical outcome dataset #1 from Smart Discharges <6m observational study. May 2017 to March, 2020 (Thrasher - <6m - Phase 1). <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Wiens, Matthew; Kabakyenga, Jerome; Kumbakumba, Elias; Businge, Stephen; Kenya-Mugisha, Nathan; Larson, Charles P; Moschovis, Peter P; Singer, Joel; Lavoie, Pascal; Dumont, Guy AM; Ansermino, J Mark; Kissoon, Niranjan — 2021-03-30 This data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 6-60 months containing <strong>pulse oximetry</strong> data.<br /> <br /><strong>Background:</strong> Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. This study aimed to refine and externally validate a previously developed post-discharge mortality prediction model.<br /> <br /><strong>Methods:</strong> In this prospective observational cohort study, we recruited 6-60-month-old children admitted with suspected sepsis from the community to the paediatric wards of four Ugandan hospitals. The primary outcome was six-month post-discharge mortality among those discharged alive. <br /> <br /><strong>Data Collection Methods:</strong> All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.<br /> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Wiens, Matthew; Kissoon, Niranjan (Tex); Ansermino, J Mark; Barigye, Celestine; Businge, Stephen; Kumbakumba, Elias; Larson, Charles; Moschovis, Peter; Singer, Joel; Lavoie, Pascal; Kabakyenga, Jerome — 2023-04-20 <br /><strong>Dataset Description:</strong> This dataset contains materials from a parent study within the <a href = "https://bcchr.ca/smart-discharges">Smart Discharges</a> program of research. Materials include the parent study protocol and associated documents. See the Metadata section below for links to related publications and datasets.<br /> <br /><strong>Background:</strong> Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. A better understanding of risk and ability to mitigate risk for those who are most vulnerable is needed to reduce child mortality in resource limited settings. <br /> <br /><strong>Methods:</strong> This is a prospective before-after study with staggered implementation at six Ugandan hospitals. Phase I is a prospective observational cohort study, while Phase II is a stepped-wedge intervention. The study also includes a long-term follow-up phase.<br /> <br />The ultimate outcome to be studied is post-discharge mortality for children < 5 years old by 6 months after admission. The study has two objectives, each corresponding to a phase: <ol><li><strong>Phase I:</strong> To refine and externally validate the existing post-discharge mortality prediction model.</li> <li><strong>Phase II: </strong> To determine the effectiveness of a Smart Discharge program on post-discharge health seeking behaviour and mortality. We also seek to lay the groundwork to study the long-term effects of sepsis on morbidity over a 10 year period.</li></ol> <br /><strong>Data Collection Methods:</strong> All data were collected at the point of care using encrypted study tablets. These data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.<br /> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16; No. 07/01-21), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679).<br /> <br /><strong>Associated datasets:</strong> <br /> <a href = "https://borealisdata.ca/dataset.xhtml?persistentId=doi:10.5683/SP3/REPMSY">Post-discharge mortality among children under 5 years admitted with suspected sepsis in Uganda: a prospective multi-site study </a><br /> <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Wiens, Matthew; Businge, Stephen; Larson, Charles P; Moschovis, Peter P; Singer, Joel; Kumbakumba, Elias; Novakowski, Stefanie; Lavoie, Pascal; Dumont, Guy AM; Ansermino, J Mark; Kabakyenga, Jerome; Kissoon, Niranjan — 2021-05-04 <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab." This data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 6-60m. <br> <br/><strong>Objective(s):</strong> Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission. <br> <br /><strong>Data Description:</strong> All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. . <br> <br /><strong>Data Processing:</strong> Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.<br> <br /><strong>Limitations:</strong> There are missing dates and the admission, discharge, and readmission dates are not in order. <br> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE).

Wiens, Matthew O; Nguyen, Vuong; Bone, Jeffrey N; Kumbakumba, Elias; Businge, Stephen; Tagoola, Abner; Sherine, Sheila Oyella; Byaruhanga, Emmanuel; Ssemwanga, Edward; Barigye, Celestine; Nsungwa, Jesca; Olaro,Charles; Ansermino, J Mark; Kissoon, Niranjan; Singer, Joel; Larson, Charles P; Lavoie, Pascal M; Dunsmuir, Dustin; Moschovis, Peter P; Novakowski, Stefanie; Komugisha, Clare; Tayebwa, Mellon; Mwesigwa, Douglas; Knappett, Martina; West, Nicholas; Kenya-Mugisha, Nathan; Kabakyenga, Jerome — 2024-07-16 <br/><strong>Background:</strong> In many low-income countries, over five percent of hospitalized children die following hospital discharge. The lack of available tools to identify those at risk of post-discharge mortality has limited the ability to make progress towards improving outcomes. We aimed to develop algorithms designed to predict post-discharge mortality among children admitted with suspected sepsis.<br /> <br /><strong>Methods:</strong> Four prospective cohort studies of children in two age groups (0–6 and 6–60 months) were conducted between 2012–2021 in six Ugandan hospitals. Prediction models were derived for six-months post-discharge mortality, based on candidate predictors collected at admission, each with a maximum of eight variables, and internally validated using 10-fold cross-validation.<br /> <br /><strong>Findings:</strong> 8,810 children were enrolled: 470 (5.3%) died in hospital; 257 (7.7%) and 233 (4.8%) post-discharge deaths occurred in the 0-6-month and 6-60-month age groups, respectively. The primary models had an area under the receiver operating characteristic curve (AUROC) of 0.77 (95%CI 0.74–0.80) for 0-6-month-olds and 0.75 (95%CI 0.72–0.79) for 6-60-month-olds; mean AUROCs among the 10 cross-validation folds were 0.75 and 0.73, respectively. Calibration across risk strata was good: Brier scores were 0.07 and 0.04, respectively. The most important variables included anthropometry and oxygen saturation. Additional variables included: illness duration, jaundice-age interaction, and a bulging fontanelle among 0-6-month-olds; and prior admissions, coma score, temperature, age-respiratory rate interaction, and HIV status among 6-60-month-olds.<br /> <br /><strong>Data Processing Methods:</strong> The post-processed data files were created using R version 4.2.2. (R Foundation for Statistical Computing, Vienna, Austria) and briefly involved renaming columns from the different datasets so that they are consistent, converting categories coded as “unknown”, “don’t know”, or “missing” to NA, creating new columns, calculating z-scored variables, and converting relevant columns to factors or dates. <br /> <br /><strong>Ethics Declaration:</strong> These studies were approved by the Mbarara University of Science and Technology (No. 15/10-16), the Uganda National Council for Science and Technology (HS 2207), and the University of British Columbia (H16-02679).<br />

Wiens, Matthew O; Kabakyenga, Jerome; Kumbakumba, Elias; Businge, Stephen; Kenya-Mugisha, Nathan; Larson, Charles P; Moschovis, Peter P; Singer, Joel; Lavoie, Pascal; Dumont, Guy AM; Ansermino, J Mark; Kissoon, Niranjan — 2024-10-22 This data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 0-6 months containing <strong>pulse oximetry</strong> data. <br /> <br /><strong>Background:</strong> Substantial mortality occurs after hospital discharge in children under 5 years old with suspected sepsis. This study aimed to refine and externally validate a previously developed post-discharge mortality prediction model.<br /> <br /><strong>Methods:</strong> In this prospective observational cohort study, we recruited 0-6-month-old children admitted with suspected sepsis from the community to the paediatric wards of six Ugandan hospitals. The primary outcome was six-month post-discharge mortality among those discharged alive. <br /> <br /><strong>Data Collection Methods:</strong> All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge.<br /> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."

Wiens, Matthew; Businge, Stephen; Tagoola, Abner; Larson, Charles P; Moschovis, Peter P; Singer, Joel; Kumbakumba, Elias; Novakowski, Stefanie; Lavoie, Pascal; Dumont, Guy AM; Ansermino, J Mark; Kabakyenga, Jerome; Kissoon, Niranjan — 2024-10-22 This data is a subset of the Smart Discharges Uganda Under 5 years parent study and is specific to the Phase I observational cohort of children aged 0-6 months. <br> <br/><strong>Objective(s):</strong> Used as part of the Smart Discharge prediction modelling for adverse outcomes such as post-discharge death and readmission. <br> <br /><strong>Data Description:</strong> All data were collected at the point of care using encrypted study tablets and these data were then uploaded to a Research Electronic Data Capture (REDCap) database hosted at the BC Children’s Hospital Research Institute (Vancouver, Canada). At admission, trained study nurses systematically collected data on clinical, social and demographic variables. Following discharge, field officers contacted caregivers at 2 and 4 months by phone, and in-person at 6 months, to determine vital status, post-discharge health-seeking, and readmission details. Verbal autopsies were conducted for children who had died following discharge. . <br> <br /><strong>Data Processing:</strong> Created z-scores for anthropometry variables using height and weight according to WHO cutoff. Distance to hospital was calculated using latitude and longitude. Extra symptom and diagnosis categories were created based on text field in these two variables. BCS score was created by summing all individual components.<br> <br /><strong>Limitations:</strong> There are missing dates and the admission, discharge, and readmission dates are not in order. <br> <br /><strong>Ethics Declaration:</strong> This study was approved by the Mbarara University of Science and Technology Research Ethics Committee (No. 15/10-16), the Uganda National Institute of Science and Technology (HS 2207), and the University of British Columbia / Children & Women’s Health Centre of British Columbia Research Ethics Board (H16-02679). This manuscript adheres to the guidelines for STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). <br /><strong>NOTE for restricted files:</strong> If you are not yet a CoLab member, please complete our <a href = "https://rc.bcchr.ca/redcap/surveys/?s=EDCYL7AC79">membership application survey</a> to gain access to restricted files within 2 business days. <br />Some files may remain restricted to CoLab members. These files are deemed more sensitive by the file owner and are meant to be shared on a case-by-case basis. Please contact the CoLab coordinator on <a href = "https://www.bcchr.ca/pediatric-sepsis-data-colab">this page</a> under "collaborate with the pediatric sepsis colab."