Etiology of hospital mortality in children living in low-and middle-income countries: a systematic review and meta-analysisLink copied to clipboard!
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- Description:
Background: In 2019, 80% of the 7.4 million global child deaths occurred in low- and middle-income countries (LMICs). Global and regional estimates of cause of hospital death and admission in LMIC children are needed to guide global and local priority setting and resource allocation but are currently lacking. The study objective was to estimate global and regional prevalence for common causes of pediatric hospital mortality and admission in LMICs.
Methods: We performed a systematic review and meta-analysis to identify LMIC observational studies published January 1, 2005-February 26, 2021. Eligible studies included: a general pediatric admission population, a cause of admission or death, and total admissions. We excluded studies with data before 2000 or without a full text. Two authors independently screened and extracted data. We performed methodological assessment using domains adapted from the Quality in Prognosis Studies tool. Data were pooled using random-effects models where possible. We reported prevalence as a proportion of cause of death or admission per 1000 admissions with 95% confidence intervals (95%CI).
Findings: ur search identified 29,637 texts. After duplicate removal and screening, we analyzed 253 studies representing 21.8 million pediatric hospitalizations in 59 LMICs. All-cause pediatric hospital mortality was 4.1% [95%CI 3.4-4.7%]. The most common causes of mortality (deaths/1000 admissions) were infectious (12 [95%CI 9-14]); respiratory (9 [95%CI 5-13]); and gastrointestinal (9 [95%CI 6-11]). Common causes of admission (cases/1000 admissions) were respiratory (255 [95%CI 231-280]); infectious (214 [95%CI193-234]); and gastrointestinal (166 [95%CI 143-190]). We observed regional variation in estimates. Pediatric hospital mortality remains high in LMICs.
Implications: Global child health efforts must include measures to reduce hospital mortality including basic emergency and critical care services tailored to the local disease burden. Resources are urgently needed to promote equity in child health research, support researchers, and collect high-quality data in LMICs to further guide priority setting and resource allocation.
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- Auteur(s) :
- Kortz, Teresa B, Mediratta, RishiUniverity of San Francisco, Smith, Audrey MStanford University, Nielsen, Katie RLeonard M. Miller School of Medicine, University of Miami, Agulnik, AsyaUniversity of Washington, Gordon Rivera, StephanieSt. June Children's Research Hospital, Reeves, HaileyUniversity of California, San Francisco, O'Brien, Nicole FUniversity of Alberta, Hau Lee, JanThe Ohio State University, Abbas, QalabSingHealth Duke-NUS Global Health Institute, Attebery, Jonah EAga Khan University, Bacha, TigistUniversity of Colorado Hospital, Bhutta, Emaan GSaint Paul Hospital Medical College, Biewen, CarterMailman School of Public Health, Camacho-Cruz, JhonUniversity of San Francisco, Munoz, Alvaro CoronadoNational University of Colombia, DeAlmeida, Mary Lhildren's Hospital at Montefiore, Domeryo Owusu, LarkoEmory University, Fonseca, YudyKomfo Anokye Teaching Hospital, Hooli, ShubhadaUniversity of Maryland, Johnson, Hunter CBaylor College of Medicine, Leimanis-Laurens, MaraThe Ohio State University, Mally, Deogratisu NicholausMichigan State University, McCarthy, Amanda MMuhimbili University of Health and Allied Sciences, Mutekanga, AndrewUniversity of Texas MD Anderson Cancer Center, Pineda, CarolMbarara University of Science and Technolog, Remy, Kenneth EBaystate Medical Center, Sanders, Sara C.Rainbow Babies & Children's Hospital, Tabor, EricaConnecticut Children's Medical Center, Rodrigues Teixeira, AdrianaUniversity of Pennsylvania, Qi Jyuee Want, JustinFederal University of Minas Gerais, Kissoon, NiranjanRoyal Brompton Hospital, Takwoingi, YemisiUniversity of British Columbia, Wiens, Matthew OUniversity of Birminghamet Bhutta, AdnanIndiana University
- Contributor(s):
- Trawin, Jessica et Kortz, Teresa B
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- Dépôt source:
- UBC Dataverse
- Series:
- Pediatric Sepsis Data CoLab // Clinical studies // PALISI // PALISI - Global Health // PALISI Global Health - Manuscripts
- Éditeur(s):
- Borealis
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- Accès:
- Restricted
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- License:
- CC BY-NC-SA 4.0
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- URL:
- https://doi.org/10.5683/SP3/2UKUKW
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- Date de publication:
- 2024-06-12
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- Sujets (en):
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- Mots-clés (en):
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- Identificateur:
- https://doi.org/10.5683/SP3/2UKUKW
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Référence bibliographique
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- Citation selon les normes APA:
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Etiology of hospital mortality in children living in low-and middle-income countries: a systematic review and meta-analysis. (2024). [Data set]. UBC Dataverse. https://doi.org/10.5683/SP3/2UKUKWRéférence copiée dans le presse-papier
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