A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla

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Description:

Multimodal microstructural MRI has shown increased sensitivity and specificity to changes in various brain disease and injury models in the preclinical setting. Here, we present an in vivo longitudinal dataset, acquired as control data and to investigate microstructural changes in the healthy mouse brain. The dataset consists of structural T2-weighted imaging, magnetization transfer ratio and saturation imaging, and advanced quantitative diffusion MRI (dMRI) methods. The dMRI methods include oscillating gradient spin echo (OGSE) dMRI and microscopic anisotropy (μA) dMRI, which provide additional insight by increasing sensitivity to smaller spatial scales and disentangling fiber orientation dispersion from true microstructural changes, respectively. The technical skills required to analyze microstructural MRI data are complex and include MRI sequence development, acquisition, and computational neuroimaging expertise. Here, we share unprocessed and preprocessed data, and scalar maps of quantitative MRI metrics. We envision utility of this dataset in the microstructural MRI field to develop and test biophysical models, methods that model temporal brain dynamics, and different registration and preprocessing pipelines.

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Auteur(s) :

Rahman, Naila

Rahman, Naila

Western University

, Xu, Kathy

Xu, Kathy

Western University

, Budde, Matthew D.

Budde, Matthew D.

Medical College of Wisconsin

, Brown, Arthur

Brown, Arthur

Western University

et Baron, Corey A.

Baron, Corey A.

Western University

Contributor(s):

Naila Rahman, Corey A. Baron, Kathy Xu, Matthew D. Budde et Arthur Brown

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Dépôt source:

FRDR

Éditeur(s):

Federated Research Data Repository / dépôt fédéré de données de recherche

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URL:

https://doi.org/10.20383/103.0594

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Date de publication:

2022-07-07

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Mots-clés (en):

Diffusion MRI, Magnetization Transfer MRI, Microstructure, Longitudinal in vivo Imaging, Multimodal MRI, Preclinical, et Rodent brain

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Citation selon les normes APA:

A longitudinal microstructural MRI dataset in healthy C57Bl/6 mice at 9.4 Tesla. (2022). [Data set]. FRDR. https://doi.org/10.20383/103.0594

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