Additional file 1 of Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Additional file 1: Table S1. Genetic variants used to instrument BMI, WHR and metabolites. Table S2. Assesment of instrument strength. Table S3. Colorectal cancer case distributions by study, sex and site. Table S4. LogOR colorectal cancer per SD higher BMI or WHR. Table S5. Beta change in NMR-detected metabolite per SD higher BMI or WHR. Table S6. LogOR colorectal cancer per SD higher BMI or WHR-driven NMR-detected metabolite. Table S7. Risk of overall colorectal cancer per SD higher adipose or metabolite trait, estimated using multivariable Mendelian randomization. Table S8. Posthoc investigations.
Auteur(s) :
Bull, Caroline J.

Bull, Caroline J.

University of Bristol
0000-0002-2176-5120
, Bell, Joshua A.

Bell, Joshua A.

University of Bristol
, Murphy, Neil

Murphy, Neil

International Agency for Research on Cancer
, Sanderson, Eleanor

Sanderson, Eleanor

University of Bristol
, Davey Smith, George

Davey Smith, George

University of Bristol
, Timpson, Nicholas J.

Timpson, Nicholas J.

University of Bristol
, Banbury, Barbara L.

Banbury, Barbara L.

Fred Hutchinson Cancer Center
, Albanes, Demetrius

Albanes, Demetrius

National Institutes of Health
, Berndt, Sonja I.

Berndt, Sonja I.

National Institutes of Health
, Bézieau, Stéphane

Bézieau, Stéphane

Centre Hospitalier Universitaire de Nantes
, Bishop, D. Timothy

Bishop, D. Timothy

University of Leeds
, Brenner, Hermann

Brenner, Hermann

German Cancer Research Center
, Buchanan, Daniel D.

Buchanan, Daniel D.

University of Melbourne Royal Melbourne Hospital
, Burnett-Hartman, Andrea

Burnett-Hartman, Andrea

Kaiser Permanente
, Casey, Graham

Casey, Graham

University of Virginia
, Castellví-Bel, Sergi

Castellví-Bel, Sergi

University of Barcelona
, Chan, Andrew T.

Chan, Andrew T.

Massachusetts General Hospital Broad Institute Brigham and Women's Hospital
, Chang-Claude, Jenny

Chang-Claude, Jenny

German Cancer Research Center University Medical Center Hamburg-Eppendorf
, Cross, Amanda J.

Cross, Amanda J.

Imperial College London
, de la Chapelle, Albert

de la Chapelle, Albert

The Ohio State University
, Figueiredo, Jane C.

Figueiredo, Jane C.

University of Southern California Cedars-Sinai Medical Center
, Gallinger, Steven J.

Gallinger, Steven J.

University of Toronto
, Gapstur, Susan M.

Gapstur, Susan M.

American Cancer Society
, Giles, Graham G.

Giles, Graham G.

Monash University University of Melbourne Cancer Council Victoria
, Gruber, Stephen B.

Gruber, Stephen B.

University of Southern California
, Gsur, Andrea

Gsur, Andrea

Medical University of Vienna
, Hampe, Jochen

Hampe, Jochen

TU Dresden
, Hampel, Heather

Hampel, Heather

The Ohio State University
, Harrison, Tabitha A.

Harrison, Tabitha A.

Fred Hutchinson Cancer Center
, Hoffmeister, Michael

Hoffmeister, Michael

German Cancer Research Center
, Hsu, Li

Hsu, Li

University of Washington Fred Hutchinson Cancer Center
, Huang, Wen-Yi

Huang, Wen-Yi

National Institutes of Health
, Huyghe, Jeroen R.

Huyghe, Jeroen R.

Fred Hutchinson Cancer Center
, Jenkins, Mark A.

Jenkins, Mark A.

University of Melbourne
, Joshu, Corinne E.

Joshu, Corinne E.

Johns Hopkins University
, Keku, Temitope O.

Keku, Temitope O.

University of North Carolina System
, Kühn, Tilman

Kühn, Tilman

German Cancer Research Center
, Kweon, Sun-Seog

Kweon, Sun-Seog

Chonnam National University Chonnam National University Hwasun Hospital
, Le Marchand, Loic

Le Marchand, Loic

University of Hawaii at Manoa
, Li, Christopher I.

Li, Christopher I.

Fred Hutchinson Cancer Center
, Li, Li

Li, Li

University of Virginia
, Lindblom, Annika

Lindblom, Annika

Karolinska University Hospital Karolinska Institute
, Martín, Vicente

Martín, Vicente

Instituto de Salud Carlos III University of Leon
, May, Anne M.

May, Anne M.

Utrecht University
, Milne, Roger L.

Milne, Roger L.

Monash University University of Melbourne Cancer Council Victoria
, Moreno, Victor

Moreno, Victor

University of Barcelona Instituto de Salud Carlos III Institut d'Investigació Biomédica de Bellvitge Institut Català d'Oncologia
, Newcomb, Polly A.

Newcomb, Polly A.

University of Washington Fred Hutchinson Cancer Center
, Offit, Kenneth

Offit, Kenneth

Cornell University Memorial Sloan Kettering Cancer Center
, Ogino, Shuji

Ogino, Shuji

Harvard University Broad Institute Dana-Farber/Harvard Cancer Center
, Phipps, Amanda I.

Phipps, Amanda I.

University of Washington Fred Hutchinson Cancer Center
, Platz, Elizabeth A.

Platz, Elizabeth A.

Johns Hopkins University
, Potter, John D.

Potter, John D.

University of Washington University of Canterbury Fred Hutchinson Cancer Center Massey University
, Qu, Conghui

Qu, Conghui

Fred Hutchinson Cancer Center
, Quirós, J. Ramón

Quirós, J. Ramón

, Rennert, Gad

Rennert, Gad

Carmel Medical Center Technion – Israel Institute of Technology
, Riboli, Elio

Riboli, Elio

Imperial College London
, Sakoda, Lori C.

Sakoda, Lori C.

Fred Hutchinson Cancer Center Kaiser Permanente
, Schafmayer, Clemens

Schafmayer, Clemens

Universitätsmedizin Rostock
, Schoen, Robert E.

Schoen, Robert E.

University of Pittsburgh Medical Center
, Slattery, Martha L.

Slattery, Martha L.

University of Utah
, Tangen, Catherine M.

Tangen, Catherine M.

Fred Hutchinson Cancer Center
, Tsilidis, Kostas K.

Tsilidis, Kostas K.

Imperial College London University of Ioannina
, Ulrich, Cornelia M.

Ulrich, Cornelia M.

University of Utah
, van Duijnhoven, Fränzel J. B.

van Duijnhoven, Fränzel J. B.

Wageningen University & Research
, van Guelpen, Bethany

van Guelpen, Bethany

Umeå University
, Visvanathan, Kala

Visvanathan, Kala

Johns Hopkins University
, Vodicka, Pavel

Vodicka, Pavel

Institute of Experimental Medicine Charles University
, Vodickova, Ludmila

Vodickova, Ludmila

Institute of Experimental Medicine Charles University
, Wang, Hansong

Wang, Hansong

University of Hawaii at Manoa
, White, Emily

White, Emily

University of Washington Fred Hutchinson Cancer Center
, Wolk, Alicja

Wolk, Alicja

Karolinska Institute
, Woods, Michael O.

Woods, Michael O.

Memorial University of Newfoundland
, Wu, Anna H.

Wu, Anna H.

University of Southern California
, Campbell, Peter T.

Campbell, Peter T.

American Cancer Society
, Zheng, Wei

Zheng, Wei

Vanderbilt University
, Peters, Ulrike

Peters, Ulrike

Fred Hutchinson Cancer Center
, Vincent, Emma E.

Vincent, Emma E.

University of Bristol
et Gunter, Marc J.

Gunter, Marc J.

International Agency for Research on Cancer
Dépôt source:
Figshare
Éditeur(s):
figshare
License:
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode
URL:
https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Adiposity_metabolites_and_colorectal_cancer_risk_Mendelian_randomization_study/13466701
Date de publication:
2020
Sujets (en):
FOS: Biological sciences, Sociology, FOS: Sociology, Medicine, Cell Biology, Biotechnology, Biological Sciences not elsewhere classified, Biochemistry, Genetics, Molecular Biology, Chemical Sciences not elsewhere classified, Physiology, Cancer, Computational Biology, Evolutionary Biology, Immunology, et FOS: Clinical medicine
Identificateur:
https://doi.org/10.6084/m9.figshare.13466701

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Additional file 1 of Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. (2020). [Data set]. Figshare. https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Adiposity_metabolites_and_colorectal_cancer_risk_Mendelian_randomization_study/13466701
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