Borealis
Pillay, Yashodani;
Ngonzi, Joseph;
Nguyen, Vuong;
Payne, Beth A.;
Komugisha, Clare;
Twinomujuni, Annet H.;
Vidler, Marianne;
Lavoie, Pascal M.;
Bebell, Lisa M.;
Christoffersen-Deb, Astrid;
Kenya-Mugisha, Nathan;
Kissoon, Niranjan;
Ansermino, J Mark;
Wiens, Matthew O
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2023-11-09
<br/><strong>Background:</strong> The first six weeks following delivery bear the most significant and persistent burden of under-5 and maternal death, and severe neonatal and maternal morbidity. Efforts are currently underway to improve outcomes immediately following births at health facilities for both mothers and newborns. However, care following facility discharge presents significant challenges and
accounts for a high proportion of maternal and neonatal death and morbidity. The objective of this study is to develop a clinical risk prediction model using maternal and
infant characteristics collected at the time of hospital discharge following a facility delivery to predict maternal or neonatal death or major morbidity within six weeks of birth. A secondary objective is to characterize the epidemiology of post-discharge mortality and morbidity for women and their infants after facility delivery. <br/>
<br /><strong>Methods:</strong> We will recruit a cohort of 3200 maternal and infant pairs after delivery at Mbarara Regional Referral Hospital to develop the risk model. This study involves prospective recruitment and data collection prior to discharge and final follow-up at six weeks postpartum for both mom and baby. Initial data collection will be completed by study research nurses as a prospective chart review and time of discharge patient assessment. Data collection will include maternal socio-demographics variables, clinical condition during admission, details of delivery and co-morbid conditions and maternal and infant vital signs at hospital discharge. Six-week follow up will be completed in person at the facility or through telephone follow-up to capture any maternal or infant adverse outcomes, including details of any re-admission to hospital, occurring after the initial discharge.<br />
<br /><strong>Ethics Declaration:</strong> Institutional review boards at the University of British Columbia (H18-02523), the Mbarara University of Science and Technology (14/09-18), and the Uganda National Council for Science and Technology (SS 4853) approved the study.<br />
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