Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal

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Description:

We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.

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Auteur(s) :

Parra, Esteban J.

Parra, Esteban J.

University of Toronto

, Mazurek, Andrew

Mazurek, Andrew

University of Toronto

, Gignoux, Christopher R.

Gignoux, Christopher R.

Stanford University

, Sockell, Alexandra

Sockell, Alexandra

Stanford University

, Agostino, Michael

Agostino, Michael

University of Toronto

, Morris, Andrew P.

Morris, Andrew P.

University of Liverpool

, Petty, Lauren E.

Petty, Lauren E.

Department of Epidemiology, Human Genetics & Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States of America

, Hanis, Craig L.

Hanis, Craig L.

Department of Epidemiology, Human Genetics & Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States of America

, Cox, Nancy J.

Cox, Nancy J.

Vanderbilt University

, Valladares-Salgado, Adan

Valladares-Salgado, Adan

Hospital de Especialidades

, Below, Jennifer E.

Below, Jennifer E.

Department of Epidemiology, Human Genetics & Environmental Sciences, University of Texas School of Public Health, Houston, TX, United States of America

et Cruz, Miguel

Cruz, Miguel

Hospital de Especialidades

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Dépôt source:

Dryad

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URL:

https://doi.org/10.5061/dryad.7ns5c

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Date de publication:

2018-02-15

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Mots-clés (en):

Fine-mapping, Admixture Mapping, BUD13/ZNF259/APOA5, Lipids, Homo Sapiens, Triglycerides, et rs964184

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Citation selon les normes APA:

Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. (2018). [Data set]. Dryad. https://doi.org/10.5061/dryad.7ns5c

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